Ganoderma lucidum – Natural Products for Fighting Cancer
Ganoderma lucidum is mushroom edible, though, because the wooden structures that are not used in a raw diet. It usually grows on trees: oak, maple and brown, the leaves fall is used as a source of nutrients. Ganoderma lucidum grown in all meridians, especially in Asia (China, Japan, and Korea).
Ganoderma lucidum is known for healing properties for thousands of years. Used in traditional Chinese medicine as the fountain of youth and longevity, it is considered a “special diet”. As it is put to use medical treatment for many diseases: heart disease, diabetes, viral infections, allergies, bronchitis, arthritis, nephritis, cancer and other conditions. Ganoderma lucidum interest for many years developing. Effects of Ganoderma observed worldwide, in vivo and in vitro. There are many preparations of Ganoderma lucidum with different levels of efficiency and effectiveness. The highest quality products extracted from mushrooms, raised in the area preserved environment, where the sample selected is not contaminated.
Specific technology used is based on a laser cutter and most critical CO 2 oxidation. In this way an oily extract of Ganoderma lucidum were obtained in high concentrations (more than 1000 higher), with all the bio-active components protect. Active components of Ganoderma lucidum were tested and the mechanism of their effects known and proven. The active chemical compounds that are essential for anti-tumor activity are: polysaccharides, proteoglycans, cerebrosides, triterpenes, triterpenoids and phenol. In addition, Ganoderma lucidum containing nucleoside, adenosine, organic germanium (Ge-132) with high antioxidant potential. Polysaccharides have demonstrated anti-tumor activity in experimental animals and cell cultures. Parts with the highest anti-tumor activity was shown to be a beta-D-glucan. The same effect is shown by Glucuronolactone, manogalactone, arabinolactone and glucogalactone. The proven ability to oncogenesis polysaccharides, avoiding tumor metastasis. Prevention of metastasis is further enhanced by activating the immune response (cell-activated cells in the immune system works, NK cells, T lymphocytes, B lymphocytes). Synthesis of cytokines: interleukin (IL) 1 beta, tumor necrosis factor (TNF) alpha, interleukin (IL) 6 and interferon (IF) stimulated gamma. These cytokines suppress the activity of enzyme systems within cells responsible for tumor cell proliferation and their work. In this way the body recognizes and active tumor cells natural mechanism to fight and destroy them.
More than 100 triterpenes very active with proven cytotoxic activity was isolated. Ganoderic acids A and C, has shown the ability to inhibit the enzyme responsible for activating the Ras oncoprotein to lead the transformation of healthy cells in the tumor. Triterpenes other remote also has a cytotoxic effect. Triterpenoid compounds inhibit tumor metastasis, inhibiting the growth of secondary tumors in the liver and spleen, as shown in animal models. They also inhibit the growth of new blood vessels around the tumor tissue and thus preventing the delivery of nutrients and oxygen to lung cells. Phenols isolated from Ganoderma lucidum have strong antioxidant activity, and inhibit lipid peroxidation. Some proteoglycans induce activation and proliferation of B lymphocytes, which causes increased secretion of interleukin 2. The cerebrosides inhibit the enzyme DNA polymerase, and thus prevent the replication of DNA, preventing the growth of tumors. Fractions of Ganoderma lucidum Aminopolysaccharide shown to reduce oxidative damage to DNA. It has chemo-preventive measures, to prevent damage to blood cells.
The total effect of all bioactive substances isolated and their anti-tumor activity that resulted in restrictions or activation of specific mechanisms and pathways to prevent the change of healthy cells in the tumor. This effect is mediated indirectly by increasing the immune response and secretion of cytokines by stimulation. Or directly, by targeting cancer cells under the influence of bioactive compounds by affecting the behavior of tumor cells, preventing them from multiplying and spreading, this has led to their destruction .
With great interest in Ganoderma lucidum and its benefits to cancer treatment. Clinical testing has shown to reduce the effects of chemotherapy and radio therapy. It enables medical mushroom to continue to implement the standard therapy, preventing anemia and leukopenia, and improve the quality of life for patients with cancer. Knowledge of medical mushrooms are the most important shows and justifies its use in treatment cancer, and avoiding this terrible disease.