Mayo Clinic(Dr. Vincent Rajkumar), Rochester, MN – The Mayo Clinic published an update of their myeloma survival rates for transplant eligible and posted it on line 12/3/2018. They reported Overall Survival (OS). OS includes death from all causes and The SEER data is based on Relative Survival which excluded non myeloma deaths. The Mayo Relative Survival rates are 95.9% at 2 years versus the SEER rate of 72% and 89.8% at 4 years versus the SEER rate of 57.7% When compared to the SEER rate you are 6 times more likely to die in 2 years and 4.1 times more likely to die in 4 years at the average SEER facility than if you were under the care of the Mayo, Rochester. You can see a graph of the data if you CLICK HERE. This data is reflected in an OS study of 518 consecutive transplant eligible patients seen at Mayo Clinic. An outline of Mayo’s risk adapted treatment template called mSmart can be found at the attached link: http://www.msmart.org/
As noted, Mayo and most programs provide their data as Overall Survival(OS), and the National Cancer Institute adjusts the data to exclude the non myeloma deaths. This measure is called Relative Survival(RS), so to make a comparison of Mayo’s information to that listed on the NCI SEER data base, I have adjusted the Mayo data to reflect Relative Survival. The graph below is this comparison.
In addition if there is to be any true cure, the Mayo graphs slope need not flatten but less than or equal to the slope of the Social Security Life Tables. If the blue line continues to run parallel or the gap between the blue and gray line does not get larger, this I might argue is the definition of cure. What this means is the remaining population of myeloma patients is dying at a pace less than or equal to the national average of all people.
The Christmas and Holiday Gift to mankind is the mSmart template published by Mayo Clinic(CLICK HERE) which outlines the process they go through to reach these excellent survival rates. If the local hematologist/oncologist throughout the world are able to follow this template for treatment and supportive care the myeloma survival throughout the world may improve significantly. This is the only open source treatment template widely available. The next step will be individualized myeloma care based on the Health Tree being co-developed by Dr. Rafael Fonseca of Mayo and Myeloma Crowd.