Dyclonine enhances the cytotoxic effect of Velcade (bortezomib) in multiple myeloma cells

sucretsIf you are taking Velcade (bortezomib), you HAVE TO read this abstract: http://goo.gl/DjYdVv

In a nutshell, dyclonine, one of the main ingredients of Sucrets (cough drops), increases the anti-MM effect of Velcade. It also “minimizes drug resistance in MM cells.” Now, there is a slight problem with this last statement: according to the Myeloma Beacon (see: http://goo.gl/x5IUXA), the minimization of drug resistance apparently occurs at higher doses than those that would be normally given to MM patients.

And another thing: we should also keep in mind that these are in vitro results…Dyclonine has been tested on a myeloma cell line, NOT on myeloma patients actually taking Velcade. So this is all preliminary stuff.

On the other hand, when I first began taking curcumin, there were only a couple of published studies on curcumin and myeloma…and, like this one, those studies were based on myeloma cell lines…

And look at me now, more than eight years later…

Well, in any event, I am always intrigued whenever I read about promising combinations of toxic and non-toxic compounds in the battle against myeloma.

Speaking of which, let’s not forget that curcumin is (among many other things!) a proteasome inhibitor, like Velcade. Combined with Velcade, curcumin has been shown to increase that drug’s ability to annihilate myeloma cells. Note: I’ve written about the curcumin-Velcade studies here on the blog, so you can look ‘em up, if you want more info.

P.S. Many thanks to the Myeloma Beacon for alerting me to this new study. :)